2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140967
    Mal-Amido-PEG4-Boc 1415800-35-9 99.84%
    Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-Amido-PEG4-Boc
  • HY-140047
    Propargyl-PEG4-sulfonic acid 1817735-29-7 98.0%
    Propargyl-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-sulfonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-sulfonic acid
  • HY-140330
    (10-BRomodecyl)phosphonic acid 934985-98-5 99.44%
    (10-BRomodecyl)phosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    (10-BRomodecyl)phosphonic acid
  • HY-134714
    DBCO-PEG3-amine 2093409-57-3 99.99%
    DBCO-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG3-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG3-amine
  • HY-77475
    1-Cbz-3-Hydroxyazetidine 128117-22-6 99.89%
    1-Cbz-3-Hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-3-Hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    1-Cbz-3-Hydroxyazetidine
  • HY-140753
    DOTA-(t-butyl)3-PEG5-azide 99.69%
    DOTA-(t-butyl)3-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DOTA-(t-butyl)3-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    DOTA-(t-butyl)3-PEG5-azide
  • HY-130507
    Aminooxy-PEG5-azide 1919045-02-5 98.0%
    Aminooxy-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Aminooxy-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aminooxy-PEG5-azide
  • HY-140970
    Mal-PEG8-alcohol 2353409-63-7
    Mal-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG8-alcohol
  • HY-130454
    Mal-PEG6-PFP ester 1599486-33-5
    Mal-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG6-PFP ester
  • HY-W009037
    Maleimide-C10-NHS ester 87981-04-2 98.0%
    Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Maleimide-C10-NHS ester
  • HY-140088
    NH-bis(PEG2-propargyl) 2100306-83-8
    NH-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    NH-bis(PEG2-propargyl)
  • HY-140926
    N-(Propargyl-PEG4)-biocytin 2055042-71-0 98.0%
    N-(Propargyl-PEG4)-biocytin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Propargyl-PEG4)-biocytin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(Propargyl-PEG4)-biocytin
  • HY-130584
    Propargyl-PEG2-MS 943726-01-0
    Propargyl-PEG2-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG2-MS is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-MS
  • HY-130150
    m-PEG5-succinimidyl carbonate 1058691-00-1 98.0%
    m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG5-succinimidyl carbonate
  • HY-141379
    N-Bromoacetyl-β-alanine 89520-11-6
    N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Bromoacetyl-β-alanine
  • HY-130882
    HS-PEG7-CH2CH2N3 2148986-06-3
    HS-PEG7-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. HS-PEG7-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    HS-PEG7-CH2CH2N3
  • HY-140808
    Azido-PEG3-C3-OH 1807512-36-2 98.0%
    Azido-PEG3-C3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-C3-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-C3-OH
  • HY-140773
    Azido-PEG8-PFP ester 2055014-62-3
    Azido-PEG8-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-PFP ester
  • HY-140976A
    Mal-amido-PEG9-amine TFA 2569576-12-9 99.37%
    Mal-amido-PEG9-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG9-amine TFA
  • HY-141265
    Methyltetrazine-PEG8-acid 2183440-33-5 99.02%
    Methyltetrazine-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG8-acid
PROTAC Linkers Isoform Comparison

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